Product Details

Name: Trimethyl(trifluoroMethyl)silane

CAS number: 81290-20-2

Molecular formula:C₄H₉F₃Si

Molecular weight: 142.2 g/mol

Purity: ≥98%

Appearance: Colorless transparent liquid

Boiling point: 53-55°C, @760mmHg

Density: 0.969 g/ml, @25 °C (lit.)

Stability: volatile

Storage: sealed at room temperature

Uses: trifluoromethylation reagent.

Packing:1KG;5KG;25KG;50KG;100KG;200KG

Application reference:

Trifluoromethyl is widely used in pharmacochemistry. Fluoxetine, developed by Lily, is the world's first listed SSRIs antidepressant drug. Due to the introduction of trifluoromethyl, Fluoxetine has unique pharmacological properties and clinical efficacy, and is favored by doctors and patients. Trifluoromethyl has the following properties:

1) Trifluoromethyl is the most lipophilic group among all substituents;

2) Due to its strong electronegativity and high stability, trifluoromethyl plays a decisive role in the regional and stereoselectivity of the biological and chemical transformation of the substrate;

3) It is particularly worth mentioning that many organic molecules containing trifluoromethyl have important physiological activities.

According to the reaction mechanism, the introduction of trifluoromethyl can be divided into three main categories: free radical trifluoromethyl, nucleophilic trifluoromethyl and electrophilic trifluoromethyl.